Cell signaling in cancer dev elopment and metastasis

Prof. Sima Lev, Department of Molecular Cell Biology


Normal cell growth and motility are controlled by complex signaling pathways that respond to diverse environmental cues, including nutrients, growth factors, hormones, and components of the extracellular matrix.

Understanding how intracellular signaling networks function in normal cells, and how they are altered in cancer cells, is a major challenge of cancer cell biology research.

The long-term goal of Prof. Lev’s studies is to define the signaling pathways and the intracellular signaling components that contribute to the development and progression of breast cancer.

Identification of signaling intermediates that affect the malignancy of different breast cancer subtypes can lead to the development of new strategies for breast cancer therapy.