Mechanisms of functional reprogramming in the tumor microenvironment

Dr. Ruth Scherz-Shouval, Department of Biological Chemistry

For tumors to expand, metastasize, and evade immune surveillance, genetically transformed cancer cells must recruit non-malignant cells, including macrophages, fibroblasts and endothelial cells.

These cells, collectively termed the tumor microenvironment, are reprogrammed to support the tumor at the expense of its host.

Dr. Shouval and her group aim to elucidate the mechanisms by which tumors reprogram their local environments.

Their goal is to provide a deeper understanding of how tumors develop into systemic malignancies, predict which tumors are more likely to do so, and design therapeutic strategies to overcome these malignancies by targeting genetically stable elements in the tumor microenvironment.