I progetti di ricerca sul cancro

Progetti di ricerca sul cancro presso il Weizmann Institute of Science

In questa sezione sono riportati tutti i progetti di ricerca sul cancro in corso al Weizmann Institute of Science, associati alle borse di studio che assegna il Sergio Lombroso Program.

Il vincitore della borsa di studio si unirà ad uno dei team di ricerca già al lavoro presso il Weizmann Institute of Science.

SSPL_01

Leukocyte trafficking

Using special flow chambers that simulate blood flow and intravital microscopy in genetically manipulated mice, Prof. Alon and his team are investigating how both endothelial and perivascular trafficking molecules promote...

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Design principles in biology

The Alon lab focuses on understanding the protein circuits that perform computations within the cell.

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Immuno-genomics

Dr. Amit studies the genomic code enabling immune cells to differentiate into specific subtypes and devise a specific response to invading pathogens.

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Programmed cell death

Prof. Kimchi’s lab is studying programmed cell death by proceeding from single-gene studies to a global network analysis.

SSPL_01

Cellular senescence in tissue damage response, cancer, and aging

Dr. Krizhanovsky is working to uncover the mechanisms of interaction of the senescent cells with their microenvironment, in order to understand the role of cellular senescence in tissue damage, cancer, and aging.

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Regulation of normal and leukemic human stem cells

Prof. Lapidot and his team are primarily focused on the activities and regulation of blood-forming (hematopoietic) stem cells.

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Cell signaling in cancer dev elopment and metastasis

The long- term goal of Prof. Lev’s studies is to define the signaling pathways and the intracellular signaling components that contribute to the development and progression of breast cancer.

SSPL_01

DNA repair, mutagenesis, and cancer

Prof. Livneh’s laboratory investigates the molecular mechanisms of DNA repair and mutagenesis and their biological role under normal and pathological conditions, primarily cancer.

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Imaging of angiogenesis

Prof. Neeman’s research centers on elucidating the mechanisms that regulate angiogenesis, using magnetic resonance and optical imaging.

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Links between regulation of gene expression and cancer

The main goals of Prof. Oren are to elucidate the processes that underlie the ability of p53 to act as a tumor suppressor and the mechanistic links between regulation of gene expression and cancer.

Genomics

p53 in normal and tumor cells

Research in Prof. Rotter’s lab is focused on revealing the mechanism by which wild-type p53 acts in normal cells and the way in which mutant p53 contributes to cancer development.

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Microenvironment of the extracellular matrix and cancer

Prof. Sagi and her lab focus on the cell microenvironment which includes the extracellular matrix.

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Functional genomics in melanoma

Prof. Samuel’s group aims to discover recurrent tumor-specific mutations in melanoma using high- throughput, whole-exome, and whole-genome sequencing approaches.

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Mechanisms of functional reprogramming in the tumor microenvironment

Dr. Shouval and her group aim to elucidate the mechanisms by which tumors reprogram their local environments.

SSPL_01

Computation and systems biology

Prof. Segal’s group develops computational models aimed at understanding how molecular components interact to carry out complex biological functions.

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Intracellular signaling pathways

Prof. Seger’s current studies focus on the mechanism by which the linear signaling cascades induce many distinct, and even opposing, physiological and pathological processes.

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Molecular mechanisms regulating differentiation and survival of B cells...

The Shachar lab follows Lymphoid homeostasis events during health and disease, focusing on three key areas...

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Tumor microenvironment and resistance to chemotherapy

The Straussman group studies different mechanisms which render cancer cells resistant to chemotherapy.

Accelerator

Epigenomics and evolution

Dr. Amos Tanay’s group is studying the physical interfaces that associate genomic information with mechanisms that interpret it in the nucleus.

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Leukemia evolution from diagnosis to relapse

Dr. Shlush and his team study leukemia evolution from diagnosis to relapse. They can detect from the blood of AML patients the non-leukemic subpopulations that were ancestral to the leukemic cells and...

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Mechanisms controlling the formation of blood and lymphatic vessels

The main interest of the Yaniv lab is to understand the mechanisms controlling the formation of blood and lymphatic vessels during embryonic development...

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Oncogenic receptor tyrosine kinases

Prof. Yarden addresses the effect of the ErbB family on the mobility of tumor cells and on their ability to cross tissue barriers.

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Genetics of childhood metabolic diseases

A physician-scientist, Dr. Erez is working to decipher the dynamics of cellular metabolism at different disease states.